Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-Related Mental Disorders (MIND-SET): Protocol for a Cross-sectional Comorbidity Study From a Research Domain Criteria Perspective

Background It is widely acknowledged that comorbidity between psychiatric disorders common. Shared and diverse underpinnings of cannot be systematically understood based on symptom-based categories mental disorders, which map poorly onto pathophysiological mechanisms. In the Measuring Integrated Novel Dimensions in Neurodevelopmental Stress-Related Mental Disorders (MIND-SET) study, we make use current concepts transcend diagnostic categories. We test this approach to problems patients with frequently occurring their comorbidities (excluding psychosis). Objective The main aim MIND-SET project determine shared specific mechanisms neurodevelopmental stress-related at different observational levels. Methods This an cross-sectional study. Data from levels as defined Research Domain Criteria (genetics, physiology, neuropsychology, system-level neuroimaging, behavior, self-report, experimental neurocognitive paradigms) are collected over four time points. Included adult (aged ?18 years), nonpsychotic, a clinical diagnosis disorder (mood disorder, anxiety or substance disorder) (autism spectrum attention-deficit/hyperactivity disorder). Individuals no past included neurotypical controls. collection started June 2016 include total 650 150 controls by 2021. data procedure includes online questionnaires three subsequent sessions (1) standardized examination, physical blood sampling; (2) psychological constructs, neuropsychological tests, biological marker (3) neuroimaging measures. Results control participants period 2022. October 2021, 95% our target. Conclusions study enables us investigate mechanistic nonpsychotic transdiagnostically. will identify both disorder-specific markers can used targets for future treatment approaches.